IL-17 and IL-22 genetic polymorphisms in HBV vaccine non- and low-responders among healthcare workers.

ABSTRACT:

Background

Healthcare workers constitute a population at high risk for HBV infection. Efficient vaccination options are available; however, the individual response to HBV vaccination may vary widely between subjects, potentially due to cytokine profiles and genetic variations. In the present study, we investigated the relationship between IL-17 and IL-22 gene polymorphisms versus non- and low-responsiveness to HBV vaccination in healthcare workers.

Methods

We selected the following IL-17 and IL-22 polymorphisms: rs4711998 (A/G) from IL-17 and rs2227501 (A/T), rs2227503 (A/G), rs1026786 (A/G) from IL-22 sequences genes. These were determined by polymerase chain reaction restriction fragment length polymorphisms.

Results

The IL-17 rs4711998 GG genotype had a significant

SUBMITTER: Borzooy Z 

PROVIDER: S-EPMC4788777 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature