HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits and diseases. However, most of them are located in the non-protein coding regions, and therefore it is challenging to hypothesize the functions of these non-coding GWAS variants. Recent large efforts such as the ENCODE and Roadmap Epigenomics projects have predicted a large number of regulatory elements. However, the target genes of these regulatory elements remain largely unknown. Chromatin conformation capture based technologies such as Hi-C can directly measure the chromatin interactions and have generated an increasingly comprehensive catalog of the interactome between the distal regulatory elements and their potential target genes. Leveraging such info

SUBMITTER: Xu Z 

PROVIDER: S-EPMC4788823 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature