Cognitive remediation versus active computer control in bipolar disorder with psychosis: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Cognitive dysfunction is a major feature of bipolar disorder with psychosis and is strongly associated with functional outcomes. Computer-based cognitive remediation has shown promise in improving cognition in patients with schizophrenia. However, despite similar neurocognitive deficits between patients with schizophrenia and bipolar disorder, few studies have extended neuroscience-based cognitive remediation programs to this population.

Methods/design

The Treatment to Enhance Cognition in Bipolar Disorder study is an investigator-initiated, parallel group, randomized, blinded clinical trial of an Internet-based cognitive remediation protocol for patients with bipolar disorder I with psychosis (n = 100). We also describe the development of our dose-matched active

SUBMITTER: Lewandowski KE 

PROVIDER: S-EPMC4788830 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature