Asthma in the elderly: the effect of choline supplementation.

ABSTRACT:

Background

Asthma in the elderly is poorly understood as very few studies have included these patients. DNA methylation can affect the expression of asthma susceptibility genes. Methyl groups can be produced through a choline dependent pathway. Asthmatics have decreased serum choline. We studied the effect of choline supplementation in elderly asthmatics and associations between different parameters at baseline.

Methods

This is a double-blind, placebo-controlled, cross-over study. Thirty asthmatics 65 years old and older were evaluated at baseline and 3, 6, 9, and 12 weeks later. They randomly received choline bitartrate 310 mg and placebo capsules twice daily for 6 weeks.

Results

Ninety percent of the study subjects were atopic and 97 % of them were using inhaled cor

SUBMITTER: Columbo M 

PROVIDER: S-EPMC4788875 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature