The Ess/Type VII secretion system of Staphylococcus aureus shows unexpected genetic diversity.

ABSTRACT:

Background

Type VII protein secretion (T7SS) is a specialised system for excreting extracellular proteins across bacterial cell membranes and has been associated with virulence in Staphylococcus aureus. The genetic diversity of the ess locus, which encodes the T7SS, and the functions of proteins encoded within it are poorly understood.

Results

We used whole genome sequence data from 153 isolates representative of the diversity of the species to investigate the genetic variability of T7SS across S. aureus. The ess loci were found to comprise of four distinct modules based on gene content and relative conservation. Modules 1 and 4, comprising of the 5' and 3' modules of the ess locus, contained the most conserved clusters of genes across the species. Module 1 contained genes e

SUBMITTER: Warne B 

PROVIDER: S-EPMC4788903 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature