Randomized double-blind safety comparison of intravenous iron dextran versus iron sucrose in an adult non-hemodialysis outpatient population: A feasibility study.

ABSTRACT:

Background

Intravenous iron therapy is a treatment option for iron deficient patients who are intolerant to oral iron or where oral iron is ineffective, but with possible adverse effects. Currently, prospective studies comparing different intravenous iron formulations are needed to determine safety and efficacy of these agents.

Methods

We conducted a prospective, double-blind, randomized controlled trial (RCT) to assess the feasibility of a trial comparing the safety of high molecular weight intravenous iron dextran, Infufer®, with intravenous iron sucrose, Venofer®, in non-hemodialysis adult outpatients. Primary outcome was the occurrence of immediate severe drug reactions.

Results

We enrolled 143 patients in a one-year period. Overall, 45/143 (31.5 %) patients (20 i

SUBMITTER: Louzada ML 

PROVIDER: S-EPMC4788943 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature