Multiple sevoflurane exposures in infant monkeys do not impact the mother-infant bond.

ABSTRACT: Exposure to general anesthesia during the postnatal period is associated with death of brain cells as well as long-term impairments in cognitive and emotional behavior in animal models. These models are critical for investigating mechanisms of pediatric anesthetic neurotoxicity as well as for testing potential strategies for preventing or mitigating this toxicity. Control conditions for anesthesia exposure involve separation of conscious infants from their mothers for variable periods of time, which could have its own effect on subsequent behavior because of stress to the mother and/or infant as a consequence of separation.We are conducting a long-term study of infant rhesus monkeys exposed three times for 4h each to sevoflurane anesthesia during the first six postnatal weeks, with a compa

SUBMITTER: Raper J 

PROVIDER: S-EPMC4789080 | biostudies-literature | 2016 Mar-Apr

REPOSITORIES: biostudies-literature