Impact of Allergic Reactions on Food-Specific IgE Concentrations and Skin Test Results.

ABSTRACT:

Background

Although there is concern that food allergy reactions may negatively affect the natural history of food allergy, the impact of reactions on food-specific IgE (sIgE) levels or skin prick test (SPT) wheal size is unknown.

Objective

To measure the effects of allergic reactions on SPT wheal size and sIgE concentrations to milk, egg, and peanut.

Methods

Participants included 512 infants with likely milk or egg allergy enrolled in a multicenter observational study. Changes in sIgE level and SPT wheal size to milk, egg, and peanut were measured before and after oral food challenge (OFC) or accidental exposure for 377 participants.

Results

The median age of the cohort at the time of analysis was 8.5 years (67% males). There were no statistically significant

SUBMITTER: Sicherer SH 

PROVIDER: S-EPMC4789127 | biostudies-literature | 2016 Mar-Apr

REPOSITORIES: biostudies-literature