Review on Haploidentical Hematopoietic Cell Transplantation in Patients with Hematologic Malignancies.

ABSTRACT: Allogenic hematopoietic cell transplantation (HSCT) is typically the preferred curative therapy for adult patients with acute myeloid leukemia, but its use has been reduced as a consequence of limited donor availability in the form of either matched-related donors (MRD) or matched-unrelated donors (MUD). Alternative options such as unrelated umbilical cord blood (UCB) transplantation and haploidentical HSCT have been increasingly studied in the past few decades to overcome these obstacles. A human leukocyte antigen- (HLA-) haploidentical donor is a recipient's relative who shares an exact haplotype with the recipient but is mismatched for HLA genes on the unshared haplotype. These dissimilarities pose several challenges to the outcomes of the patient receiving such a type of HSCT, includin

SUBMITTER: Fabricius WA 

PROVIDER: S-EPMC4789357 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature