A Novel Brain Network Construction Method for Exploring Age-Related Functional Reorganization.

ABSTRACT: The human brain undergoes complex reorganization and changes during aging. Using graph theory, scientists can find differences in topological properties of functional brain networks between young and elderly adults. However, these differences are sometimes significant and sometimes not. Several studies have even identified disparate differences in topological properties during normal aging or in age-related diseases. One possible reason for this issue is that existing brain network construction methods cannot fully extract the "intrinsic edges" to prevent useful signals from being buried into noises. This paper proposes a new subnetwork voting (SNV) method with sliding window to construct functional brain networks for young and elderly adults. Differences in the topological properties of b

SUBMITTER: Li W 

PROVIDER: S-EPMC4789383 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature