DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina.

ABSTRACT: Intestinal helminths cause iron-deficiency anemia in pregnant women, associated with premature delivery, low birth weight, maternal ill health, and maternal death. Although benzimidazole compounds such as mebendazole (MBZ) are highly efficacious against helminths, there are limited data on its use during pregnancy. In this study, we performed in vivo imaging of the retinas of zebrafish larvae exposed to MBZ, and found that exposure to MBZ during 2 and 3 days post-fertilization caused malformation of the retinal layers. To identify the molecular mechanism underlying the developmental toxicity of MBZ, we performed transcriptome analysis of zebrafish eyes. The analysis revealed that the DNA damage response was involved in the developmental toxicity of MBZ. We were also able to demonstrate tha

SUBMITTER: Sasagawa S 

PROVIDER: S-EPMC4789406 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature