The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon.

ABSTRACT:

Objective

ATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria. Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical outcomes in thyroid cancer. Mechanisms underlying this observation have not been proposed, nor is it clear whether an association between Thr300Ala and clinical outcomes will be observed in other cancers. We hypothesised that Thr300Ala influences clinical outcome in human colorectal cancer (CRC) and controls innate antiviral pathways in colon cancer cells.

Design

We genotyped 460 patients with CRC and assessed for an association between ATG16L1 Thr300Ala and overall survival and clinica

SUBMITTER: Grimm WA 

PROVIDER: S-EPMC4789828 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature