Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis.

ABSTRACT:

Purpose

Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk.

Materials and methods

The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity.

Results

A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582

SUBMITTER: He L 

PROVIDER: S-EPMC4789843 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature