The role of semaphorin 4D as a potential biomarker for antiangiogenic therapy in colorectal cancer.

ABSTRACT:

Background

Semaphorin 4D (Sema4D) belongs to the class IV semaphorins, and accumulating evidence has indicated that its elevated level may be one strategy by which tumors evade current anti-angiogenic therapies. The biological roles of Sema4D in colorectal cancer (CRC), however, remain largely undefined. This study was designed to investigate the effects of Sema4D on tumor angiogenesis and growth in CRC, especially in different vascular endothelial growth factor (VEGF) backgrounds.

Methods

The expression of Sema4D in human CRC was evaluated by immunohistochemical analysis of tumors and their matching normal control tissues. The expression level of Sema4D and VEGF was investigated in different CRC cell lines. To evaluate the contributions of Sema4D to tumor-induced angiogenes

SUBMITTER: Ding X 

PROVIDER: S-EPMC4789851 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature