Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression.

ABSTRACT:

Background

Understanding how embryos specify asymmetric axes is a major focus of biology. While much has been done to discover signaling pathways and transcription factors important for axis specification, comparatively little is known about how epigenetic regulators are involved. Epigenetic regulators operate downstream of signaling pathways and transcription factors to promote nuclear processes, most prominently transcription. To discover novel functions for these complexes in axis establishment during early embryonic development, we characterized phenotypes of a mouse knockout (KO) allele of the chromatin remodeling Ino80 ATPase.

Results

Ino80 KO embryos implant, but fail to develop beyond the egg cylinder stage. Ino80 KO embryonic stem cells (ESCs) are viable and maintai

SUBMITTER: Qiu Z 

PROVIDER: S-EPMC4790052 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature