Effects of Levothyroxine Replacement or Suppressive Therapy on Energy Expenditure and Body Composition.

ABSTRACT:

Background

Thyrotropin (TSH)-suppressive doses of levothyroxine (LT4) have adverse effects on bone and cardiac function, but it is unclear whether metabolic function is also affected. The objective of this study was to determine whether women receiving TSH-suppressive LT4 doses have alterations in energy expenditure or body composition.

Methods

This study was a cross-sectional comparison between three groups of women: 26 women receiving chronic TSH-suppressive LT4 doses, 80 women receiving chronic replacement LT4 doses, and 16 untreated euthyroid control women. Subjects underwent measurements of resting energy expenditure (REE), substrate oxidation, and thermic effect of food by indirect calorimetry; physical activity energy expenditure by accelerometer; caloric intake by 24

SUBMITTER: Samuels MH 

PROVIDER: S-EPMC4790206 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature