Essential Tremor: What We Can Learn from Current Pharmacotherapy.

ABSTRACT:

Background

The pathophysiology of essential tremor, especially at the cellular level, is poorly understood. Although no drug has been specifically designed to treat essential tremor, several medications improve tremor, and others worsen it. Studying the mechanism of actions of these medications can help our understanding of tremor pathophysiology and contribute to future rational drug design.

Methods

We reviewed literature, concentrating on mechanisms of action, of various medications that mitigate tremor.

Results

Many medications have multiple mechanisms of actions, making simple correlations difficult. Medications that increase the duration of opening of gamma-aminobutyric acid (GABA)-A receptors are most consistently associated with tremor improvement. Interestingl

SUBMITTER: Ondo W 

PROVIDER: S-EPMC4790207 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature