Fecal Microbiota Transplantation: Expanding Horizons for Clostridium difficile Infections and Beyond.

ABSTRACT: Fecal Microbiota Transplantation (FMT) methodology has been progressively refined over the past several years. The procedure has an extensive track record of success curing Clostridium difficile infection (CDI) with remarkably few adverse effects. It achieves similar levels of success whether the CDI occurs in the young or elderly, previously normal or profoundly ill patients, or those with CDI in Inflammatory Bowel Disease (IBD). While using FMT to treat CDI, however, we learned that using the procedure in other gastrointestinal (GI) diseases, such as IBD without CDI, generally fails to effect cure. To improve results in treating other non-CDI diseases, innovatively designed Randomized Controlled Trials (RCTs) will be required to address questions about mechanisms operating within particu

SUBMITTER: Borody TJ 

PROVIDER: S-EPMC4790284 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature