Resistance to Antimicrobials Mediated by Efflux Pumps in Staphylococcus aureus.

ABSTRACT: Resistance mediated by efflux has been recognized in Staphylococcus aureus in the last few decades, although its clinical relevance has only been recognized recently. The existence of only a few studies on the individual and overall contribution of efflux to resistance phenotypes associated with the need of well-established methods to assess efflux activity in clinical isolates contributes greatly to the lack of solid knowledge of this mechanism in S. aureus. This study aims to provide information on approaches useful to the assessment and characterization of efflux activity, as well as contributing to our understanding of the role of efflux to phenotypes of antibiotic resistance and biocide tolerance in S. aureus clinical isolates. The results described show that efflux is an important co

SUBMITTER: Costa SS 

PROVIDER: S-EPMC4790300 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature