Correlating Photoreceptor Mosaic Structure to Clinical Findings in Stargardt Disease.

ABSTRACT:

Purpose

To demonstrate a method for correlating photoreceptor mosaic structure with optical coherence tomography (OCT) and microperimetry findings in patients with Stargardt disease.

Methods

A total of 14 patients with clinically diagnosed Stargardt disease were imaged using confocal and split-detection adaptive optics scanning light ophthalmoscopy. Cone photoreceptors were identified manually in a band along the temporal meridian. Resulting values were compared to a normative database (n = 9) to generate cone density deviation (CDD) maps. Manual measurement of outer nuclear layer plus Henle fiber layer (ONL+HFL) thickness was performed, in addition to determination of the presence of ellipsoid zone (EZ) and interdigitation zone (IZ) bands on OCT. These results, along

SUBMITTER: Razeen MM 

PROVIDER: S-EPMC4790429 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature