Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release.

ABSTRACT: Implant-associated infections are undesirable complications that might arise after implant surgery. If the infection is not prevented, it can lead to tremendous cost, trauma, and even life threatening conditions for the patient. Development of an implant coating loaded with antimicrobial substances would be an effective way to improve the success rate of implants. In this study, the in vitro efficacy of mesoporous titania thin films used as a novel antimicrobial release coating was evaluated. Mesoporous titania thin films with pore diameters of 4, 6, and 7 nm were synthesized using the evaporation-induced self-assembly method. The films were characterized and loaded with antimicrobial agents, including vancomycin, gentamicin, and daptomycin. Staphylococcus aureus and Pseudomonas aeruginosa

SUBMITTER: Atefyekta S 

PROVIDER: S-EPMC4790524 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature