Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245 Klebsiella pneumoniae clones circulating in Spain.

ABSTRACT:

Objectives

The global emergence of OXA-48-producing Klebsiella pneumoniae clones is a significant threat to public health. We used WGS and phylogenetic analysis of Spanish isolates to investigate the population structure of blaOXA-48-like-expressing K. pneumoniae ST11 and ST405 and to determine the distribution of resistance genes and plasmids encoding blaOXA-48-like carbapenemases.

Methods

SNPs identified in whole-genome sequences were used to reconstruct phylogenetic trees, identify resistance determinants and de novo assemble the genomes of 105 blaOXA-48-like-expressing K. pneumoniae isolates.

Results

Genome variation was generally lower in outbreak-associated isolates compared with those associated with sporadic infections. The relatively limited variation observe

SUBMITTER: Perez-Vazquez M 

PROVIDER: S-EPMC4790626 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature