Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits.

ABSTRACT: Recent progress in understanding the diversity of midbrain dopamine neurons has highlighted the importance--and the challenges--of defining mammalian neuronal cell types. Although neurons may be best categorized using inclusive criteria spanning biophysical properties, wiring of inputs, wiring of outputs, and activity during behavior, linking all of these measurements to cell types within the intact brains of living mammals has been difficult. Here, using an array of intact-brain circuit interrogation tools, including CLARITY, COLM, optogenetics, viral tracing, and fiber photometry, we explore the diversity of dopamine neurons within the substantia nigra pars compacta (SNc). We identify two parallel nigrostriatal dopamine neuron subpopulations differing in biophysical properties, input wir

SUBMITTER: Lerner TN 

PROVIDER: S-EPMC4790813 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature