Detailed Report on 2014/15 Influenza Virus Characteristics, and Estimates on Influenza Virus Vaccine Effectiveness from Austria's Sentinel Physician Surveillance Network.

ABSTRACT:

Background

Influenza vaccine effectiveness (VE) is influenced by the antigenic similarity between vaccine- and circulating strains.

Material and methods

This paper presents data obtained by the Austrian sentinel surveillance system on the evolution of influenza viruses during the season 2014/15 and its impact on influenza vaccine effectiveness in primary care in Austria as estimated by a test-negative case control design. VE estimates were performed for each influenza virus type/subtype, stratified by underlying diseases and adjusted for age, sex and calendar week of infection.

Results

Detailed genetic and antigenic analyses showed that circulating A(H3N2) viruses were genetically distinct from the 2014/15 A(H3N2) vaccine component indicating a profound vaccine mismat

SUBMITTER: Redlberger-Fritz M 

PROVIDER: S-EPMC4790898 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature