Identification of a common neurobiological substrate for mental illness.

ABSTRACT:

Importance

Psychiatric diagnoses are currently distinguished based on sets of specific symptoms. However, genetic and clinical analyses find similarities across a wide variety of diagnoses, suggesting that a common neurobiological substrate may exist across mental illness.

Objective

To conduct a meta-analysis of structural neuroimaging studies across multiple psychiatric diagnoses, followed by parallel analyses of 3 large-scale healthy participant data sets to help interpret structural findings in the meta-analysis.

Data sources

PubMed was searched to identify voxel-based morphometry studies through July 2012 comparing psychiatric patients to healthy control individuals for the meta-analysis. The 3 parallel healthy participant data sets included resting-state function

SUBMITTER: Goodkind M 

PROVIDER: S-EPMC4791058 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature