The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint.

ABSTRACT: We compare the functional spectrum of protein evolution in two separate animal lineages with respect to two hypotheses: (1) rates of divergence are distributed similarly among functional classes within both lineages, indicating that selective pressure on the proteome is largely independent of organismic-level biological requirements; and (2) rates of divergence are distributed differently among functional classes within each lineage, indicating species-specific selective regimes impact genome-wide substitutional patterns. Integrating comparative genome sequence with data from tissue-specific expressed-sequence-tag (EST) libraries and detailed database annotations, we find a functional genomic signature of rapid evolution and selective constraint shared between mammalian and nematode lineag

SUBMITTER: Castillo-Davis CI 

PROVIDER: S-EPMC479106 | biostudies-literature | 2004 May

REPOSITORIES: biostudies-literature