Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis.

ABSTRACT: Mild cognitive impairment (MCI) is an acquired syndrome characterised by cognitive decline not affecting activities of daily living. Using a quantitative meta-analytic approach, we aimed to identify consistent neuroanatomic correlates of MCI and how they are related to cognitive dysfunction. The meta-analysis enrols 22 studies, involving 917 MCI (848 amnestic MCI) patients and 809 healthy controls. Only studies investigating local changes in grey matter and reporting whole-brain results in stereotactic coordinates were included and analysed using the activation likelihood estimation approach. Probabilistic cytoarchitectonic maps were used to compare the localization of the obtained significant effects to histological areas. A correlation between the probability of grey matter changes and c

SUBMITTER: Nickl-Jockschat T 

PROVIDER: S-EPMC4791066 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature