Validation of a new T2* algorithm and its uncertainty value for cardiac and liver iron load determination from MRI magnitude images.

ABSTRACT:

Purpose

To validate an automatic algorithm for offline T2* measurements, providing robust, vendor-independent T2*, and uncertainty estimates for iron load quantification in the heart and liver using clinically available imaging sequences.

Methods

A T2* region of interest (ROI)-based algorithm was developed for robustness in an offline setting. Phantom imaging was performed on a 1.5 Tesla system, with clinically available multiecho gradient-recalled-echo (GRE) sequences for cardiac and liver imaging. A T2* single-echo GRE sequence was used as reference. Simulations were performed to assess accuracy and precision from 2000 measurements. Inter- and intraobserver variability was obtained in a patient study (n = 23).

Results

Simulations: Accuracy, in terms of the mean diff

SUBMITTER: Bidhult S 

PROVIDER: S-EPMC4791092 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature