Ontology highlight
ABSTRACT:
SUBMITTER: Vougiouklakis T
PROVIDER: S-EPMC4791223 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Oncotarget 20151201 41
The oncogenic protein ERK, a member of the extracellular signal-regulated kinase (ERK) cascade, is a well characterized signaling molecule involved in tumorigenesis. The ERK signaling pathway is activated in a large proportion of cancers and plays a critical role in tumor development. Functional regulation by phosphorylation of kinases in the ERK pathway has been extensively studied, however methylation of the ERK protein has not been reported to date. Here, we demonstrated that the protein lysi ...[more]