Comprehensive multiplatform biomarker analysis of 199 anal squamous cell carcinomas.

ABSTRACT: Anal squamous cell carcinoma (ASCC) is a rare, HPV-associated malignancy typically diagnosed in early stages and definitively treated with chemoradiation. In situations where patients exhibit metastatic or recurrent disease, treatment options are severely limited. In this study, molecular alterations were identified that could be used to aid in therapeutic decisions for patients with metastatic or recurrent anal squamous cell carcinoma. Specimens from patients with this cancer were tested via a multiplatform profiling service (Caris Life Sciences, Phoenix, AZ) consisting of gene sequencing, protein expression by immunohistochemistry, and gene amplification with in situ hybridization. Utilizing these techniques, novel treatment strategies that could be explored were identified, including po

SUBMITTER: Smaglo BG 

PROVIDER: S-EPMC4791253 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature