The Evolutionarily Conserved E3 Ubiquitin Ligase AtCHIP Contributes to Plant Immunity.

ABSTRACT: Plants possess a sophisticated immune system to recognize and respond to microbial threats in their environment. The level of immune signaling must be tightly regulated so that immune responses can be quickly activated in the presence of pathogens, while avoiding autoimmunity. HSP90s, along with their diverse array of co-chaperones, forms chaperone complexes that have been shown to play both positive and negative roles in regulating the accumulation of immune receptors and regulators. In this study, we examined the role of AtCHIP, an evolutionarily conserved E3 ligase that was known to interact with chaperones including HSP90s in multicellular organisms including fruit fly, Caenorhabditis elegans, plants and human. Atchip knockout mutants display enhanced disease susceptibility to a virule

SUBMITTER: Copeland C 

PROVIDER: S-EPMC4791365 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature