Alterations of Functional and Structural Networks in Schizophrenia Patients with Auditory Verbal Hallucinations.

ABSTRACT:

Background

There have been many attempts at explaining the underlying neuropathological mechanisms of auditory verbal hallucinations (AVH) in schizophrenia on the basis of regional brain changes, with the most consistent findings being that AVH are associated with functional and structural impairments in auditory and speech-related regions. However, the human brain is a complex network and the global topological alterations specific to AVH in schizophrenia remain unclear.

Methods

Thirty-five schizophrenia patients with AVH, 41 patients without AVH, and 50 healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI). The whole-brain functional and structural networks were constructed and analyzed using graph theoreti

SUBMITTER: Zhu J 

PROVIDER: S-EPMC4791368 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature