Impact of New Genomic Technologies on Understanding Adverse Drug Reactions.

ABSTRACT: It is well established that variations in genes can alter the pharmacokinetic and pharmacodynamic profile of a drug and immunological responses to it. Early advances in pharmacogenetics were made with traditional genetic techniques such as functional cloning of genes using knowledge gained from purified proteins, and candidate gene analysis. Over the past decade, techniques for analysing the human genome have accelerated greatly as knowledge and technological capabilities have grown. These techniques were initially focussed on understanding genetic factors of disease, but increasingly they are helping to clarify the genetic basis of variable drug responses and adverse drug reactions (ADRs). We examine genetic methods that have been applied to the understanding of ADRs, review the current s

SUBMITTER: Maggo SD 

PROVIDER: S-EPMC4791456 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature