Tuberculosis in Cape Town: An age-structured transmission model.

ABSTRACT:

Background

Tuberculosis (TB) is the leading cause of death in South Africa. The burden of disease varies by age, with peaks in TB notification rates in the HIV-negative population at ages 0-5, 20-24, and 45-49 years. There is little variation between age groups in the rates in the HIV-positive population. The drivers of this age pattern remain unknown.

Methods

We developed an age-structured simulation model of Mycobacterium tuberculosis (Mtb) transmission in Cape Town, South Africa. We considered five states of TB progression: susceptible, infected (latent TB), active TB, treated TB, and treatment default. Latently infected individuals could be re-infected; a previous Mtb infection slowed progression to active disease. We further considered three states of HIV progression: H

SUBMITTER: Blaser N 

PROVIDER: S-EPMC4791535 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature