Continuous time Bayesian networks identify Prdm1 as a negative regulator of TH17 cell differentiation in humans.

ABSTRACT: T helper 17 (TH17) cells represent a pivotal adaptive cell subset involved in multiple immune disorders in mammalian species. Deciphering the molecular interactions regulating TH17 cell differentiation is particularly critical for novel drug target discovery designed to control maladaptive inflammatory conditions. Using continuous time Bayesian networks over a time-course gene expression dataset, we inferred the global regulatory network controlling TH17 differentiation. From the network, we identified the Prdm1 gene encoding the B lymphocyte-induced maturation protein 1 as a crucial negative regulator of human TH17 cell differentiation. The results have been validated by perturbing Prdm1 expression on freshly isolated CD4(+) naïve T cells: reduction of Prdm1 expression leads to augmentati

SUBMITTER: Acerbi E 

PROVIDER: S-EPMC4791550 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature