Soluble TWEAK and Major Adverse Cardiovascular Events in Patients with CKD.

ABSTRACT:

Background and objectives

Soluble TNF-like weak inducer of apoptosis (sTWEAK) is a proinflammatory cytokine belonging to the TNF superfamily. sTWEAK concentrations have been associated with the presence of CKD and cardiovascular disease (CVD). We hypothesized that sTWEAK levels may relate to a higher prevalence of atherosclerotic plaques, vascular calcification, and cardiovascular outcomes observed in patients with CKD.

Design, setting, participants, & measurements

A 4-year prospective, multicenter, longitudinal study was conducted in 1058 patients with CKD stages 3-5D (mean age =58±13 years old; 665 men) but without any history of CVD from the NEFRONA Study (a study design on the prevalence of surrogate markers of CVD). Ankle-brachial index and B-mode ultrasound were perfor

SUBMITTER: Fernandez-Laso V 

PROVIDER: S-EPMC4791813 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature