Visit-to-Visit Variability of BP and CKD Outcomes: Results from the ALLHAT.

ABSTRACT:

Background and objectives

Increased visit-to-visit variability of BP is associated with cardiovascular disease risk. We examined the association of visit-to-visit variability of BP with renal outcomes among 21,245 participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.

Design, setting, participants, & measurements

We measured mean BP and visit-to-visit variability of BP, defined as SD, across five to seven visits occurring 6-28 months after participants were randomized to chlorthalidone, amlodipine, or lisinopril. The composite outcome included incident ESRD after assessment of SD of systolic BP or ≥50% decline in eGFR between 24 months and 48 or 72 months after randomization. We repeated the analyses using average real variability an

SUBMITTER: Whittle J 

PROVIDER: S-EPMC4791814 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature