Treatment with Glucocorticoids or Calcineurin Inhibitors in Primary FSGS.

ABSTRACT:

Background and objectives

In primary FSGS, calcineurin inhibitors have primarily been studied in patients deemed resistant to glucocorticoid therapy. Few data are available about their use early in the treatment of FSGS. We sought to estimate the association between choice of therapy and ESRD in primary FSGS.

Design, setting, participants, & measurements

We used an inception cohort of patients diagnosed with primary FSGS by kidney biopsy between 1980 and 2012. Factors associated with initiation of therapy were identified using logistic regression. Time-dependent Cox models were performed to compare time to ESRD between different therapies.

Results

In total, 458 patients were studied (173 treated with glucocorticoids alone, 90 treated with calcineurin inhibitors with o

SUBMITTER: Laurin LP 

PROVIDER: S-EPMC4791818 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature