Spatiotemporal variation of mammalian protein complex stoichiometries.

ABSTRACT:

Background

Recent large-scale studies revealed cell-type specific proteomes. However, protein complexes, the basic functional modules of a cell, have been so far mostly considered as static entities with well-defined structures. The co-expression of their members has not been systematically charted at the protein level.

Results

We used measurements of protein abundance across 11 cell types and five temporal states to analyze the co-expression and the compositional variations of 182 well-characterized protein complexes. We show that although the abundance of protein complex members is generally co-regulated, a considerable fraction of all investigated protein complexes is subject to stoichiometric changes. Compositional variation is most frequently seen in complexes involved

SUBMITTER: Ori A 

PROVIDER: S-EPMC4791834 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature