Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells.

ABSTRACT:

Background

Expression of the microRNA miR-21 has been found to be altered in almost all types of cancers and it has been classified as an oncogenic microRNA or oncomir. Due to the critical functions of its target proteins in various signaling pathways, miR-21 is an attractive target for genetic and pharmacological modulation in various cancers. Cervical cancer is the second most common cause of death from cancer in women worldwide and persistent HPV infection is the main etiologic agent. This malignancy merits special attention for the development of new treatment strategies. In the present study we analyze the role of miR-21 in cervical cancer cells.

Methods

To identify the downstream cellular target genes of upstream miR-21, we silenced endogenous miR-21 expression in a ce

SUBMITTER: Peralta-Zaragoza O 

PROVIDER: S-EPMC4791868 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature