The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems.

ABSTRACT:

Background

The genome of Mycobacterium tuberculosis contains five copies of the ESX gene cluster, each encoding a dedicated protein secretion system. These ESX secretion systems have been defined as a novel Type VII secretion machinery, responsible for the secretion of proteins across the characteristic outer mycomembrane of the mycobacteria. Some of these secretion systems are involved in virulence and survival in M. tuberculosis; however they are also present in other non-pathogenic mycobacteria, and have been identified in some non-mycobacterial actinomycetes. Three components of the ESX gene cluster have also been found clustered in some gram positive monoderm organisms and are predicted to have preceded the ESX gene cluster.

Results

This study used in silico and phyloge

SUBMITTER: Newton-Foot M 

PROVIDER: S-EPMC4791881 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature