Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential.

ABSTRACT:

Background

The neonatal murine heart is able to regenerate after severe injury; this capacity however, quickly diminishes and it is lost within the first week of life. DNA methylation is an epigenetic mechanism which plays a crucial role in development and gene expression regulation. Under investigation here are the changes in DNA methylation and gene expression patterns which accompany the loss of regenerative potential.

Results

The MeDIP-chip (methylated DNA immunoprecipitation microarray) approach was used in order to compare global DNA methylation profiles in whole murine hearts at day 1, 7, 14 and 56 complemented with microarray transcriptome profiling. We found that the methylome transition from day 1 to day 7 is characterized by the excess of genomic regions which gai

SUBMITTER: Gornikiewicz B 

PROVIDER: S-EPMC4791959 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature