Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas.

ABSTRACT: The reported associations with gastric adenocarcinoma and seropositivity to different Helicobacter pylori antigens using multiplex serology have not been consistent across studies. We aimed to investigate the association between 15 different multiplex serology antigens and the risk of gastric cardia (GCA) and gastric noncardia (GNCA) adenocarcinomas in northeastern Iran, a population with high rates of gastric adenocarcinoma. We included 272 cases of gastric adenocarcinoma (142 GCA, 103 GNCA, and 27 unspecified) and 524 controls who were individually matched to cases for age, sex, and place of residence in a population-based case-control study. Seropositivity to H. pylori was assessed using both multiplex serology and H. pylori IgG ELISA. Ninety-five percent of controls were seropositive t

SUBMITTER: Shakeri R 

PROVIDER: S-EPMC4792189 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature