A constitutive model for developing blood clots with various compositions and their nonlinear viscoelastic behavior.

ABSTRACT: The mechanical properties determine to a large extent the functioning of a blood clot. These properties depend on the composition of the clot and have been related to many diseases. However, the various involved components and their complex interactions make it difficult at this stage to fully understand and predict properties as a function of the components. Therefore, in this study, a constitutive model is developed that describes the viscoelastic behavior of blood clots with various compositions. Hereto, clots are formed from whole blood, platelet-rich plasma and platelet-poor plasma to study the influence of red blood cells, platelets and fibrin, respectively. Rheological experiments are performed to probe the mechanical behavior of the clots during their formation. The nonlinear visco

SUBMITTER: van Kempen TH 

PROVIDER: S-EPMC4792371 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature