Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis.

ABSTRACT: Cancer cells often rely on glycolysis to obtain energy and support anabolic growth. Several studies showed that glycolytic cells are susceptible to cell death when subjected to low glucose availability or to lack of glucose. However, some cancer cells, including glycolytic ones, can efficiently acquire higher tolerance to glucose depletion, leading to their survival and aggressiveness. Although increased resistance to glucose starvation has been shown to be a consequence of signaling pathways and compensatory metabolic routes activation, the full repertoire of the underlying molecular alterations remain elusive. Using omics and computational analyses, we found that cyclic adenosine monophosphate-Protein Kinase A (cAMP-PKA) axis activation is fundamental for cancer cell resistance to glucos

SUBMITTER: Palorini R 

PROVIDER: S-EPMC4792400 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature