PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins.

ABSTRACT: Proteins with expanded polyglutamine (polyQ) repeats are involved in human neurodegenerative diseases, via a gain-of-function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposition of β-sheet-rich aggregates. Aggregation is dependent on the context and properties of the host protein, such as domain context and location of the repeat tract. In order to explore this relationship in greater detail, here we describe PolyQ 2.0, an updated database that provides a comprehensive knowledgebase for human polyQ proteins. Compared with the previous PolyQ database, our new database provides a variety of substantial updates including detailed biological annotations and search options. Biological annotations in terms of domain context informat

SUBMITTER: Li C 

PROVIDER: S-EPMC4792530 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature