X-ray Phase Contrast Allows Three Dimensional, Quantitative Imaging of Hydrogel Implants.

ABSTRACT: Three dimensional imaging techniques are needed for the evaluation and assessment of biomaterials used for tissue engineering and drug delivery applications. Hydrogels are a particularly popular class of materials for medical applications but are difficult to image in tissue using most available imaging modalities. Imaging techniques based on X-ray Phase Contrast (XPC) have shown promise for tissue engineering applications due to their ability to provide image contrast based on multiple X-ray properties. In this manuscript, we investigate the use of XPC for imaging a model hydrogel and soft tissue structure. Porous fibrin loaded poly(ethylene glycol) hydrogels were synthesized and implanted in a rodent subcutaneous model. Samples were explanted and imaged with an analyzer-based XPC techniq

SUBMITTER: Appel AA 

PROVIDER: S-EPMC4792647 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature