Inhibition of Adenosine Kinase Attenuates Acute Lung Injury.

ABSTRACT:

Objectives

Extracellular adenosine has tissue-protective potential in several conditions. Adenosine levels are regulated by a close interplay between nucleoside transporters and adenosine kinase. On the basis of the evidence of the role of adenosine kinase in regulating adenosine levels during hypoxia, we evaluated the effect of adenosine kinase on lung injury. Furthermore, we tested the influence of a pharmacologic approach to blocking adenosine kinase on the extent of lung injury.

Design

Prospective experimental animal study.

Setting

University-based research laboratory.

Subjects

In vitro cell lines, wild-type and adenosine kinase+/- mice.

Interventions

We tested the expression of adenosine kinase during inflammatory stimulation in vitro and in a model

SUBMITTER: Kohler D 

PROVIDER: S-EPMC4792660 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature