Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome.

ABSTRACT:

Objectives

In acute respiratory distress syndrome, conservative fluid management increases ventilator-free days without affecting mortality. Response to fluid management may differ based on patients' initial central venous pressure. We hypothesized that initial central venous pressure would modify the effect of fluid management on outcomes.

Design

Retrospective analysis of the Fluid and Catheter Treatment Trial, a multicenter randomized trial comparing conservative with liberal fluid management in acute respiratory distress syndrome. We examined the relationship between initial central venous pressure, fluid strategy, and 60-day mortality in univariate and multivariable analysis.

Setting

Twenty acute care hospitals.

Patients

Nine hundred thirty-four ventilated

SUBMITTER: Semler MW 

PROVIDER: S-EPMC4792704 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature