Development of a High-Throughput Ultrasound Technique for the Analysis of Tissue Engineering Constructs.

ABSTRACT: Development of hydrogel-based tissue engineering constructs is growing at a rapid rate, yet translation to patient use has been sluggish. Years of costly preclinical tests are required to predict clinical performance and safety of these devices. The tests are invasive, destructive to the samples and, in many cases, are not representative of the ultimate in vivo scenario. Biomedical imaging has the potential to facilitate biomaterial development by enabling longitudinal noninvasive device characterization directly in situ. Among the various available imaging modalities, ultrasound stands out as an excellent candidate due to low cost, wide availability, and a favorable safety profile. The overall goal of this work was to demonstrate the utility of clinical ultrasound in longitudinal characte

SUBMITTER: Stukel JM 

PROVIDER: S-EPMC4792737 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature